Pathophysiology of Glaucomatous Optic Neuropathy: Role of Optic Nerve Head Vascular Insufficiency
نویسندگان
چکیده
منابع مشابه
Pathophysiology of Glaucomatous Optic Neuropathy: Role of Optic Nerve Head Vascular Insufficiency
In 1970, based on my experimental and clinical studies, I defined glaucoma as: “a disease wherein the normal balance between the intraocular pressure and the blood pressure in the choroidal vessels supplying the optic disc and retrolaminar part of the optic nerve is disturbed, resulting in vascular insufficiency in the optic disc and retrolaminar part of the optic nerve, and hence in visual fie...
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OBJECTIVES To compare the optic nerve head (ONH) structure between compressive optic neuropathy (CON) and glaucomatous optic neuropathy (GON), and to determine whether selected ONH quantitative parameters effectively discriminate between GON and CON, especially CON cases presenting with a glaucoma-like disc. METHODS We prospectively assessed 34 patients with CON, 34 age-matched patients with ...
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glaucoma is a major cause of worldwide irreversible blindness. the central role of raised intraocular pressure (iop) is being questioned as many patients continue to demonstrate a clinically downhill course despite initial control of iop. the latest concept of recognizing glaucoma as a multifactorial, progressive, neurodegenerative disease of retinal ganglion cells (rgcss) associated with chara...
متن کاملReproducibility of topographic measures of the glaucomatous optic nerve head.
AIMS/BACKGROUND Laser scanning tomography provides an assessment of three dimensional optic disc topography. For the clinical purpose of follow up of glaucoma patients, the repeatability of the various measured variables is essential. In the present study, the reproducibility of morphometric variables calculated by the topographic scanning system, TopSS (Laser Diagnostic Technology, San Diego, ...
متن کاملEvaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage.
PURPOSE To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy. METHODS Chronic elevation of rat intraocular pressure (IOP) leading to optic nerve damage was induced by episcleral injection of hypertonic saline, which caused sclerosis and blockade of aqueous humor outflow pathways. Expression of NOS-2 in the retina and optic nerve head (ONH) ...
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ژورنال
عنوان ژورنال: Current Journal of Glaucoma Practice with DVD
سال: 2008
ISSN: 0974-0333,0975-1947
DOI: 10.5005/jp-journals-10008-1018